Ho Lab

The Ho Lab is located in the Helen Diller Research Building at the UCSF Mission Bay campus in the Department of Neurological Surgery. Our lab focuses on developing novel therapeutics for pediatric brain tumors and translating bench work to clinical trials.

 

 

Immune cells
Cancer intrinsic mechanisms that mediate immune evasion in pediatric brain cancer and glioblastoma

We are currently developing a novel immunotherapy to enhance immunogenicity of pediatric brain tumors including DIPG and medulloblastoma as well as adult glioblastoma to sensitize to immune checkpoint blockade.

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Medulloblastoma
Regulation of Senescence in p53 mutant medulloblastoma

Medulloblastoma is the most common malignant central nervous system tumor in children. We are investigating novel therapies to target medulloblastoma by regulating senescence pathway in p53 mutant medulloblastoma with the worst prognosis.

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PP2A holoenzyme crystal structure
PP2A as a novel immunotherapy target

We identified the role of PP2A in mediating tumor response, and are currently developing novel therapeutics targeting this enzyme. 

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